Nationally, about 45% of MD applicants and about 63% of DO applicants were accepted somewhere during the 2025 cycle, per AAMC and AACOM figures. That's the share of all applicants who matched with at least one school, not the odds at any specific program.
Individual schools are far more selective than that headline number suggests, often admitting in the single digits of their applicant pool. A school's overall acceptance rate tells you almost nothing useful about your personal odds there — your stats relative to that school's actual matriculant range tell you far more, which is exactly what a well-built school list should be based on.